Research Facilities | Department of Biochemistry and Molecular Biophysics

UCSD supports a number of Research Facilities that provide access to high-end instrumentation analysis. Members of the department, as well as other researchers, are encouraged to take advantage of these facilities to expand their research objectives. The facilities include mass spectrometry, biophysical instrumentation, cryoEM, x-ray, and NMR. Most of the facilities are staffed by Ph.D.-level professionals who provide training, and high-quality molecular analyses.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (cryo-EM) and cryogenic electron tomography (cryo-ET) are powerful methods for revealing the structural components of the living world utilizing electron microscopes and electron detectors that enable researchers to see beyond the reach of traditional light and confocal microscopy. The cryo-EM facility at UC San Diego is dedicated to providing the tools and expertise necessary to facilitate the study of cellular and macromolecular structures through use of single-particle and tomographic techniques.

NMR Facilities

Department of Chemistry and Biochemistry NMR Facility. Our primary focus is to provide UCSD researchers and external users with access to NMR services and state of the art NMR equipment. The facility is subdivided into two centers: the Chemistry NMR facility, located in Pacific Hall, and the Biomolecular NMR facility, located in the basement of the Natural Science Building.

Proteomics and Biomolecular Mass Spectrometry Facility

Biomolecular and Proteomics Mass Spectrometry Facility

The overall goals of the Biomolecular/Proteomics Mass Spectrometry Facility are to collaborate with university of California San Diego (UCSD) researchers and to collect the highest quality mass spectrometry data possible on biological samples. The facility is actively engaged in developing proteomic technologies and also provides access to more routine instrumentation for protein and peptide mass spec analyses.

Molecular Mass Spectrometry Facility

The molecular mass spectrometry facility (MMSF) in the Department of Chemistry and Biochemistry has been established to serve the needs of the entire UCSD community. The MMSF is one of the Technical Support Facilities in the Chemistry and Biochemistry Department. Our goal is to provide high quality MS analysis with available technical and educational resources so that researchers can obtain data with a full understanding of their implications.

The MMSF provide routine MS analysis on various types of samples including synthetic organic molecules, synthetic peptides, natural products, organometallic compounds, intact proteins, and oligonucleotides. For peptide sequencing, protein identification, and protein post-translational modifications, please contact the personnel in the Biomolecular MS Facility.